Rv1644

Tuberculist information
Gene nametsnR
Protein functionPossible 23S rRNA methyltransferase TsnR
Functional category(tuberculist)information pathways
Gene location(kb)1853.61
Molecular mass(da)26848
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 260
	  		  	1    VLTERSARVATAVKLHRHVGRRRAGRFLAEGPNLVAAALARGLVREVFVTEVAARRHELL   60
			  	61   LAAHEASVHLVTERAAKALSDTVTPAGLVAVCDLPATRLEDVLAGSPQLIAVTVEIREPG  120
			  	121  NAGTVIRIADAMGAAAVILAGRSVDPYNGKCLRASTGSIFAIPVVVAPDVGAAIADLRAA  180
			  	181  GLQVLATAVDGEMALDDADRLLAEPTAWLFGPEAHGLSAEIAALADHRVHILMSGGAESL  240
			  	241  NVAAAAAICLYESARALGRR

Known structures in the PDB
No Known structures
1 27 53 79 105 131 157 183 209 235 261 Range: 28 to 98  |  Coverage: 26% SpoU_sub_bind Range: 108 to 251  |  Coverage: 55% SpoU_methylase Range: 1 to 257  |  Coverage: 98% 1 Range: 92 to 259  |  Coverage: 64% 1 Range: 1 to 260  |  Coverage: 99% 2
Number of amino acids : 260
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
SpoU_sub_bindPF0803228-98
SpoU_methylasePF00588108-251
Mtb Structural Proteome models
Model Number1
Model nameRv1644
Template1IPA    APDBCREDO
Template coverage3_261
Template Identity(%)33.5
Model coverage(%)98.5
Normalized DOPE score0.118

Structure Models from Chopin
Model Number1
Profilec.116.1.1
Click for model details
zscore33.62
Residue begin92
Residue end259
Model Number2
Profilec.116.1.1 - 3.40.1280.10
Click for model details
zscore16.32
Residue begin1
Residue end260
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1644Gene nameConfidence Score
Rv1643rplT0.948
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions