Rv1130

Tuberculist information
Gene nameprpD
Protein functionPossible methylcitrate dehydratase PrpD
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1254.56
Molecular mass(da)57750.6
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 526
	  		  	1    VPDQDTKVRFFRVFCWCPVLRMVRIMLMHAVRAWRSADDFPCTEHMAYKIAQVAADPVDV   60
			  	61   DPEVADMVCNRIIDNAAVSAASMVRRPVTVARHQALAHPVRHGAKVFGVEGSYSADWAAW  120
			  	121  ANGVAARELDFHDTFLAADYSHPADNIPPLVAVAQQLGVCGAELIRGLVTAYEIHIDLTR  180
			  	181  GICLHEHKIDHVAHLGPAVAAGIGTMLRLDQETIYHAIGQALHLTTSTRQSRKGAISSWK  240
			  	241  AFAPAHAGKVGIEAVDRAMRGEGSPAPIWEGEDGVIAWLLAGPEHTYRVPLPAPGEPKRA  300
			  	301  ILDSYTKQHSAEYQSQAPIDLACRLRERIGDLDQIASIVLHTSHHTHVVIGTGSGDPQKF  360
			  	361  DPDASRETLDHSLPYIFAVALQDGCWHHERSYAPERARRSDTVALWHKISTVEDPEWTRR  420
			  	421  YHCADPAKKAFGARAEVTLHSGEVIVDELAVADAHPLGTRPFERKQYVEKFTELADGVVE  480
			  	481  PVEQQRFLAVVESLADLESGAVGGLNVLVDPRVLDKAPVIPPGIFR

Known structures in the PDB
No Known structures
1 53 105 157 209 261 313 365 417 469 521 Range: 40 to 505  |  Coverage: 88% MmgE_PrpD Range: 50 to 514  |  Coverage: 88% 1 Range: 1 to 511  |  Coverage: 96% 1
Number of amino acids : 526
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
MmgE_PrpDPF0397240-505
Mtb Structural Proteome models
Model Number1
Model nameRv1130
Template1SZQ    APDBCREDO
Template coverage19_483
Template Identity(%)23.0
Model coverage(%)88.2
Normalized DOPE score-0.196

Structure Models from Chopin
Model Number1
Profilee.44.1.1
Click for model details
zscore44.2
Residue begin1
Residue end511
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1130Gene nameConfidence Score
Rv1131prpC0.997
Rv1129cRv1129c0.965
Rv1129cRv1129c0.965
Rv1129cRv1129c0.965
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions