Rv0985c

Tuberculist information
Gene namemscL
Protein functionPossible large-conductance ion mechanosensitive channel MscL
Functional category(tuberculist)cell wall and cell processes
Gene location(kb)1101.03
Molecular mass(da)16023.5
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 151
	  		  	1    MLKGFKEFLARGNIVDLAVAVVIGTAFTALVTKFTDSIITPLINRIGVNAQSDVGILRIG   60
			  	61   IGGGQTIDLNVLLSAAINFFLIAFAVYFLVVLPYNTLRKKGEVEQPGDTQVVLLTEIRDL  120
			  	121  LAQTNGDSPGRHGGRGTPSPTDGPRASTESQ

Known structures in the PDB
PDB ID2OAR
Total residue count870
Number of chains5
MethodX-RAY
Resolution3.5
1 16 31 46 61 76 91 106 121 136 151 Range: 1 to 124  |  Coverage: 81% MscL Range: 11 to 118  |  Coverage: 70% 1 Range: 10 to 118  |  Coverage: 71% 1
Number of amino acids : 151
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
MscLPF017411-124
Mtb Structural Proteome models
Model Number1
Model nameRv0985c
Template1MSL    APDBCREDO
Template coverage11_118
Template Identity(%)100.0
Model coverage(%)70.9
Normalized DOPE score2.142

Structure Models from Chopin
Model Number1
Profilef.16.1.1
Click for model details
zscore18.11
Residue begin10
Residue end118
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0985cGene nameConfidence Score
Rv0992cRv0992c0.924
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions