Rv0974c

Tuberculist information
Gene nameaccD2
Protein functionProbable acetyl-/propionyl-CoA carboxylase (beta subunit) AccD2
Functional category(tuberculist)lipid metabolism
Gene location(kb)1085.76
Molecular mass(da)56224.3
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 529
	  		  	1    VLQSTLDPNASAYDEAAATMSGKLDEINAELAKALAGGGPKYVDRHHARGNLTPRERIEL   60
			  	61   LVDPDSPFLELSPLAAYGSNFQIGASLVTGIGAVCGVECMIVANDPTVKGGTSNPWTLRK  120
			  	121  ILRANQIAFENRLPVISLVESGGADLPTQKEIFIPGGQMFRDLTRLSAAGIPTIALVFGN  180
			  	181  STAGGAYVPGMSDHVVMIKERSKVFLAGPPLVKMATGEESDDESLGGAEMHARISGLADY  240
			  	241  FALDELDAIRIGRRIVARLNWIKQGPAPAPVTEPLFDAEELIGIVPPDLRIPFDPREVIA  300
			  	301  RIVDGSEFDEFKPLYGSSLVTGWARLHGYPLGILANARGVLFSEESQKATQFIQLANRAD  360
			  	361  TPLLFLHNTTGYMVGKDYEEGGMIKHGSMMINAVSNSTVPHISLLIGASYGAGHYGMCGR  420
			  	421  AYDPRFLFAWPSAKSAVMGGAQLSGVLSIVARAAAEARGQQVDEAADAAMRAAVEGQIEA  480
			  	481  ESLPLVLSGMLYDDGVIDPRDTRTVLGMCLSAIANGPIKGTSNFGVFRM

Known structures in the PDB
No Known structures
1 53 105 157 209 261 313 365 417 469 521 Range: 45 to 526  |  Coverage: 90% Carboxyl_trans Range: 17 to 525  |  Coverage: 96% 1 Range: 1 to 503  |  Coverage: 94% 1
Number of amino acids : 529
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Carboxyl_transPF0103945-526
Mtb Structural Proteome models
Model Number1
Model nameRv0974c
Template1ON3    APDBCREDO
Template coverage10_523
Template Identity(%)31.8
Model coverage(%)95.8
Normalized DOPE score-0.094

Structure Models from Chopin
Model Number1
Profilec.14.1.4
Click for model details
zscore11.15
Residue begin1
Residue end503
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0974cGene nameConfidence Score
Rv0973caccA20.98
Rv0973caccA20.98
Rv0973caccA20.98
Rv0973caccA20.98
Rv0976cRv0976c0.973
Rv0971cechA70.929
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
propionyl-CoAPubChem0.926823.597
methylmalonyl-CoAPubChem0.919867.607
bicarbonatePubChem0.91662.0248
coenzyme APubChem0.91767.534
L-methylmalonyl-CoAPubChem0.9867.607
protiumPubChem0.92.01576
H(+)PubChem0.92.01588
methyl-malonyl-coenzyme APubChem0.9862.567
NAD+PubChem0.9663.425
n-propionyl-CoAPubChem0.9823.597
adenosine diphosphatePubChem0.9427.201
phosphatePubChem0.996.9872
(2S)-methylmalonyl-CoAPubChem0.9867.607
carbon dioxidePubChem0.944.0095
methylmalonyl-coenzyme APubChem0.9867.607
methyl-malonyl-CoAPubChem0.9867.607
CHEBI:15466PubChem0.9867.607
deuteriumPubChem0.92.01588
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
alpha-ketobutyratePubChem0.9102.089
reduced nicotinamide adenine dinucleotidePubChem0.9665.441
Co-APubChem0.9767.534
adenosine triphosphatePubChem0.9507.181