Rv0648

Tuberculist information
Gene nameRv0648
Protein functionAlpha-mannosidase
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)742.719
Molecular mass(da)129949
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 1215
	  		  	1    VMGGTYNEPNTNLTSPETTIRNLVHGIGFQRDVLGAEPATAWQLDVFGHDPQFPGLAADA   60
			  	61   GLTSSSWARGPHHQWGPAQGGVDRMQFCSEFEWIAPSGRGLLTHYMPAHYSAGWSMDSST  120
			  	121  SLADAEAATYALFDQLKKVALTRNVLLPVGTDYTPPNKWVTAIHRDWGARYTWPRFVCAL  180
			  	181  PKEFFAAVRAELAKRGWVPSPQTRDMNPIYTGKDVSYIDTKQANRAAENAVLEAERFAVF  240
			  	241  AALLTGAEYPQAALAKAWVQLAYGAHHDAITGSESDQVYLDLLTGWRDAWELGRAARDNS  300
			  	301  LRLLSGAVAASHDRVVVWNPLTQRRTDIVTARVDPPLQAGVRVFDPDGAEVAALVEHDGR  360
			  	361  SVTWLACDVPSLGWRVYRLVPADEAPGWELVPGTDIANEHYRLAVDPERGGALSSLVQDG  420
			  	421  RQLIAAGRVANELALYEEYPSHPTQGEGPWHLLPTGPVVCSSACPAQVQAYRGPLGQRLV  480
			  	481  VRGRIGTLLRYTQTLTLWDGVDRVDCRTSIDEFTGEDRLLRLRWPCPVPGAMPISEVGDA  540
			  	541  VVGRGFALLHEGPESVDTAQHPWTLDNPAYGWFGLSSAVRVRAGDGVRAVSVAEVVSPTE  600
			  	601  TVSGPMARDLMVALVRAGVTATCSGADKPRYGHLDVDSNLPDARIALGGPDRNTFTKAVL  660
			  	661  AEAAPAYTAELQRQLAKTGTARVWVPAANPLARAWLPGADLRAPCALPVLVIDGRDEKHL  720
			  	721  RAAVASLADDLADAEIVVHQRAAPQMEPFEDRTVALLNRGVPSFAVDSEGTLHTALMRSC  780
			  	781  TGWPSGVWIDQPRRTAPDGSNFQLQHWTHHFDYALVCGGGDWRRAGIPARSAQFSHPLLA  840
			  	841  VAPRRPQGELPAVGSLLHVEPADSVQLGALKAAGNPLAAGSARPVQPAAVALRLVQTTGA  900
			  	901  DTPVTIGCELGKVGALRPADLLETPLAMARARKSSIDLHGYQVATVLARLDVAADMANVL  960
			  	961  AADDVALAPHAETAQPQYARYWLHNRGPAPLGGLPAVAHLHPRRVRGQPGDDVVLRLTAA 1020
			  	1021 SDCTDSVLGGVVDVVCPLGWPATPARLPFTLGAGAHLQADIALSIPAGAPPGPYPVRAQL 1080
			  	1081 RVVDTAVPAAWRQVVEDVCVVTVGADSDLEELVYLVDGPADIELAAGDRARLAVTIGSRA 1140
			  	1141 HAELALDAHSISPWGTWEWIGPPALGAVLPARGMAKLAFDVTPPAWLEPGQWWALVRVGC 1200
			  	1201 AGQLVYSPAVKVSVT

Known structures in the PDB
No Known structures
1 122 243 364 485 606 727 848 969 1090 1211 Range: 1 to 211  |  Coverage: 17% Glyco_hydro_38 Range: 209 to 286  |  Coverage: 6% Alpha-mann_mid Range: 313 to 529  |  Coverage: 17% Glyco_hydro_38C Range: 744 to 947  |  Coverage: 16% Glyco_hydro_38C Range: 1007 to 1083  |  Coverage: 6% NPCBM_assoc Range: 1 to 759  |  Coverage: 62% 1 Range: 1 to 211  |  Coverage: 17% 1 Range: 209 to 286  |  Coverage: 6% 2 Range: 1007 to 1083  |  Coverage: 6% 3
Number of amino acids : 1215
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Glyco_hydro_38PF010741-211
Alpha-mann_midPF09261209-286
Glyco_hydro_38CPF07748313-529
Glyco_hydro_38CPF07748744-947
NPCBM_assocPF106331007-1083
Mtb Structural Proteome models
Model Number1
Model nameRv0648
Template1QWN    APDBCREDO
Template coverage160_1042
Template Identity(%)17.3
Model coverage(%)62.4
Normalized DOPE score0.828

Structure Models from Chopin
Model Number1
Profilec.6.2.1
Click for model details
zscore17.23
Residue begin1
Residue end211
Model Number2
Profile1.20.1270.50
Click for model details
zscore9.15
Residue begin209
Residue end286
Model Number3
Profile2.60.40.1150
Click for model details
zscore4.75
Residue begin1007
Residue end1083
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0648Gene nameConfidence Score
Rv0649fabD20.966
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions