Rv0251c

Tuberculist information
Gene namehsp
Protein functionHeat shock protein Hsp (heat-stress-induced ribosome-binding protein A)
Functional category(tuberculist)virulence,detoxification and adaptaion
Gene location(kb)302.173
Molecular mass(da)17785.9
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 159
	  		  	1    MNNLALWSRPVWDVEPWDRWLRDFFGPAATTDWYRPVAGDFTPAAEIVKDGDDAVVRLEL   60
			  	61   PGIDVDKDVNVELDPGQPVSRLVIRGEHRDEHTQDAGDKDGRTLREIRYGSFRRSFRLPA  120
			  	121  HVTSEAIAASYDAGVLTVRVAGAYKAPAETQAQRIAITK

Known structures in the PDB
No Known structures
1 16 31 46 61 76 91 106 121 136 151 Range: 46 to 158  |  Coverage: 70% HSP20 Range: 14 to 156  |  Coverage: 89% 1 Range: 32 to 159  |  Coverage: 79% 1
Number of amino acids : 159
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
HSP20PF0001146-158
Mtb Structural Proteome models
Model Number1
Model nameRv0251c
Template1GME    APDBCREDO
Template coverage10_150
Template Identity(%)28.4
Model coverage(%)89.3
Normalized DOPE score0.482

Structure Models from Chopin
Model Number1
Profileb.15.1.1 - 2.60.40.790
Click for model details
zscore23.13
Residue begin32
Residue end159
Binding pockets
STRING
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Protein interacting with Rv0251cGene nameConfidence Score
Rv0350dnaK0.932
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions