Rv0195

Tuberculist information
Gene nameRv0195
Protein functionPossible two component transcriptional regulatory protein (probably LuxR-family)
Functional category(tuberculist)regulatory proteins
Gene location(kb)230.899
Molecular mass(da)23073.8
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 211
	  		  	1    MAPVNVISVAVVASDPLTRDGALARLSSHRELDVRAWQAGCETSVLLVLATTITAPLLCQ   60
			  	61   IEDVQKDGPSHAPKLVVVADEFSAEQVFRMIKLGLTGLLYRSQSTFDCIVETIRLSAEGR  120
			  	121  LRLPERVQRYLVGRIKSTPTAEPDTPCAAALAEREVAVLRLLADGLSTHQVAVQLNYCER  180
			  	181  TIKNIVHDIVTRLKLRNRTHAVAHALRAGLI

Known structures in the PDB
No Known structures
1 22 43 64 85 106 127 148 169 190 211 Range: 148 to 205  |  Coverage: 27% GerE Range: 8 to 201  |  Coverage: 91% 1 Range: 5 to 211  |  Coverage: 97% 1 Range: 146 to 211  |  Coverage: 30% 2 Range: 1 to 124  |  Coverage: 58% 3
Number of amino acids : 211
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
GerEPF00196148-205
Mtb Structural Proteome models
Model Number1
Model nameRv0195
Template1A04    APDBCREDO
Template coverage8_206
Template Identity(%)23.4
Model coverage(%)91.5
Normalized DOPE score-0.168

Structure Models from Chopin
Model Number1
Profilea.4.6.2, c.23.1.1 - 1.10.10.10, 3.40.50.2300
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zscore29.82
Residue begin5
Residue end211
Model Number2
Profilea.4.6.2 - 1.10.10.10
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zscore18.73
Residue begin146
Residue end211
Model Number3
Profilec.23.1.2 - 3.40.50.2300
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zscore4.04
Residue begin1
Residue end124
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0195Gene nameConfidence Score
Rv2027cdosT0.945
Rv2027cdosT0.945
Rv2027cdosT0.945
Rv2027cdosT0.945
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions