Rv0155

Tuberculist information
Gene namepntAa
Protein functionProbable NAD(P) transhydrogenase (subunit alpha) PntAa [first part; catalytic part] (pyridine nucleotide transhydrogenase subunit alpha) (nicotinamide nucleotide transhydrogenase subunit alpha)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)183.622
Molecular mass(da)37693.9
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 366
	  		  	1    MTDPQTQSTRVGVVAESGPDERRVALVPKAVASLVNRGVAVVVEAGAGERALLPDELYTA   60
			  	61   VGASIGDAWAADVVVKVAPPTAAEVGRLRGGQTLIGFLAPRNADNSIGALTQAGVQAFAL  120
			  	121  EAIPRISRAQVMDALSSQANVSGYKAVLLAASESTRFFPMLTTAAGTVKPATVLVLGVGV  180
			  	181  AGLQALATAKRLGARTTGYDVRPEVADQVRSVGAQWLDLGISASGEGGYARELTDDERAQ  240
			  	241  QQKALEEAISGFDVVITTALVPGRPAPTLVTAAAVEAMKPGSVVVDLAGETGGNCELTEP  300
			  	301  GRTVVKHDVTIAAPLNLPATMPEHASELYSKNITALLDLLIKDGRLAPDFDDEVIAQSCV  360
			  	361  TRGKDS

Known structures in the PDB
No Known structures
1 37 73 109 145 181 217 253 289 325 361 Range: 12 to 142  |  Coverage: 35% AlaDh_PNT_N Range: 151 to 313  |  Coverage: 44% AlaDh_PNT_C Range: 9 to 365  |  Coverage: 97% 1 Range: 9 to 196  |  Coverage: 51% 1 Range: 151 to 313  |  Coverage: 44% 2
Number of amino acids : 366
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
AlaDh_PNT_NPF0522212-142
AlaDh_PNT_CPF01262151-313
Mtb Structural Proteome models
Model Number1
Model nameRv0155
Template1L7D    APDBCREDO
Template coverage1_373
Template Identity(%)44.3
Model coverage(%)97.3
Normalized DOPE score-0.324

Structure Models from Chopin
Model Number1
Profile3.40.50.1770
Click for model details
zscore35.28
Residue begin9
Residue end196
Model Number2
Profilec.2.1.4
Click for model details
zscore11.44
Residue begin151
Residue end313
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0155Gene nameConfidence Score
Rv0156pntAb0.999
Rv0157pntB0.999
Rv1695ppnK0.92
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
NAD+PubChem0.984663.425
NADPPubChem0.98744.413
NADP(H)PubChem0.979745.421
reduced nicotinamide adenine dinucleotidePubChem0.958665.441
dihydronicotinamide formycin dinucleotidePubChem0.9665.441