Rv0020c

Tuberculist information
Gene namefhaA
Protein functionConserved protein with FHA domain, FhaA
Functional category(tuberculist)regulatory proteins
Gene location(kb)23.861
Molecular mass(da)56880.3
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 527
	  		  	1    MGSQKRLVQRVERKLEQTVGDAFARIFGGSIVPQEVEALLRREAADGIQSLQGNRLLAPN   60
			  	61   EYIITLGVHDFEKLGADPELKSTGFARDLADYIQEQGWQTYGDVVVRFEQSSNLHTGQFR  120
			  	121  ARGTVNPDVETHPPVIDCARPQSNHAFGAEPGVAPMSDNSSYRGGQGQGRPDEYYDDRYA  180
			  	181  RPQEDPRGGPDPQGGSDPRGGYPPETGGYPPQPGYPRPRHPDQGDYPEQIGYPDQGGYPE  240
			  	241  QRGYPEQRGYPDQRGYQDQGRGYPDQGQGGYPPPYEQRPPVSPGPAAGYGAPGYDQGYRQ  300
			  	301  SGGYGPSPGGGQPGYGGYGEYGRGPARHEEGSYVPSGPPGPPEQRPAYPDQGGYDQGYQQ  360
			  	361  GATTYGRQDYGGGADYTRYTESPRVPGYAPQGGGYAEPAGRDYDYGQSGAPDYGQPAPGG  420
			  	421  YSGYGQGGYGSAGTSVTLQLDDGSGRTYQLREGSNIIGRGQDAQFRLPDTGVSRRHLEIR  480
			  	481  WDGQVALLADLNSTNGTTVNNAPVQEWQLADGDVIRLGHSEIIVRMH

Known structures in the PDB
PDB ID2LC0
Total residue count132
Number of chains1
MethodNMR
ResolutionN/A
PDB ID2LC1
Total residue count100
Number of chains1
MethodNMR
ResolutionN/A
PDB ID3OUN
Total residue count445
Number of chains2
MethodX-RAY
Resolution2.7
PDB ID3PO8
Total residue count100
Number of chains1
MethodX-RAY
Resolution1.5
PDB ID3POA
Total residue count112
Number of chains2
MethodX-RAY
Resolution2.01
1 53 105 157 209 261 313 365 417 469 521 Range: 8 to 123  |  Coverage: 21% DUF3662 Range: 455 to 518  |  Coverage: 11% FHA Range: 427 to 524  |  Coverage: 18% 1 Range: 455 to 518  |  Coverage: 11% 1 Range: 8 to 111  |  Coverage: 19% 2
Number of amino acids : 527
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
DUF3662PF124018-123
FHAPF00498455-518
Mtb Structural Proteome models
Model Number1
Model nameRv0020c
Template1UHT    APDBCREDO
Template coverage1_109
Template Identity(%)40.8
Model coverage(%)18.4
Normalized DOPE score-0.789

Structure Models from Chopin
Model Number1
Profileb.26.1.2 - 2.60.200.20
Click for model details
zscore15.9
Residue begin455
Residue end518
Model Number2
Profiled.52.5.1
Click for model details
zscore4.13
Residue begin8
Residue end111
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0020cGene nameConfidence Score
Rv0014cpknB0.978
Rv0014cpknB0.978
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions