Rv3644c

Tuberculist information
Gene nameRv3644c
Protein functionPossible DNA polymerase
Functional category(tuberculist)information pathways
Gene location(kb)4081.52
Molecular mass(da)41784.5
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 401
	  		  	1    MSGVFTRLVGQQAVEAELLATAKAARRDSAHSAGGGGTMTHAWLLTGPPGSGRSVAALCF   60
			  	61   AAALQCTSGGEPGCGRCRACTTTLAGTHADVRRVIPEGLSIGVDEMRAIVQIAARRPTTG  120
			  	121  HWQIVVIEDADRLTEGAANALLKVVEEPPPSTVFLLCAPSVDPEDIAVTLRSRCRHVALV  180
			  	181  TPSTHAIAQVLSDGDGLDPDTANWAASVSGGHVGRARRLATDPQARQRRERALGLARDAA  240
			  	241  TPSRAYAAAEELVAGAEAEALALTAQRIEAETEELRTALGAGGTGKGTGAALRGATGAMK  300
			  	301  DLERRQKSRQTRASRDALDRALIDLATYFRDALLVAAHAGGVRANHPDMADRVAALAAHA  360
			  	361  PPERLLRCIEAVLACREALAVNVKPKFAVDAMVATIGQELR

Known structures in the PDB
No Known structures
1 41 81 121 161 201 241 281 321 361 401 Range: 30 to 183  |  Coverage: 38% DNA_pol3_delta2 Range: 3 to 397  |  Coverage: 98% 1 Range: 33 to 182  |  Coverage: 37% 1
Number of amino acids : 401
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
DNA_pol3_delta2PF1317730-183
Mtb Structural Proteome models
Model Number1
Model nameRv3644c
Template1JR3    APDBCREDO
Template coverage13_357
Template Identity(%)21.7
Model coverage(%)98.0
Normalized DOPE score0.775

Structure Models from Chopin
Model Number1
Profilec.37.1.24
Click for model details
zscore9.74
Residue begin33
Residue end182
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3644cGene nameConfidence Score
Rv0321dcd0.922
Rv1617pykA0.914
Rv1617pykA0.914
Rv1021Rv10210.91
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
thymidine triphosphatePubChem0.9482.168
deoxyadenosine triphosphatePubChem0.9491.182
deoxyguanosine triphosphatePubChem0.9507.181
deoxycytidine triphosphatePubChem0.9467.157