SInCRe - Rv3283

Tuberculist information

Gene name	sseA
Protein function	Probable thiosulfate sulfurtransferase SseA (rhodanese) (thiosulfate cyanide transsulfurase) (thiosulfate thiotransferase)
Functional category(tuberculist)	intermediary metabolism and respiration
Gene location(kb)	3664.93
Molecular mass(da)	33288.4
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 297

	  		  	1    VPLPADPSPTLSAYAHPERLVTADWLSAHMGAPGLAIVESDEDVLLYDVGHIPGAVKIDW   60
			  	61   HTDLNDPRVRDYINGEQFAELMDRKGIARDDTVVIYGDKSNWWAAYALWVFTLFGHADVR  120
			  	121  LLNGGRDLWLAERRETTLDVPTKTCTGYPVVQRNDAPIRAFRDDVLAILGAQPLIDVRSP  180
			  	181  EEYTGKRTHMPDYPEEGALRAGHIPTAVHIPWGKAADESGRFRSREELERLYDFINPDDQ  240
			  	241  TVVYCRIGERSSHTWFVLTHLLGKADVRNYDGSWTEWGNAVRVPIVAGEEPGVVPVV

Known structures in the PDB

	PDB ID	3HZU
	Total residue count	318
	Number of chains	1
	Method	X-RAY
	Resolution	2.1

Number of amino acids : 297

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
Rhodanese	PF00581	22-132
Rhodanese	PF00581	162-280

Mtb Structural Proteome models

Model Number	1
Model name	Rv3283_3hzu_A
Template	3HZU APDB CREDO
Template coverage	3_294
Template Identity(%)	100.0
Model coverage(%)	98.0
Normalized DOPE score	-1.98

Model Number	2
Model name	Rv3283
Template	1UAR APDB CREDO
Template coverage	2_285
Template Identity(%)	52.0
Model coverage(%)	93.3
Normalized DOPE score	-1.069

Structure Models from Chopin

Model Number	1
Profile	c.46.1.2 Click for model details
zscore	16.48
Residue begin	1
Residue end	279

Binding pockets

STRING

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Protein interacting with Rv3283	Gene name	Confidence Score
Rv3284	Rv3284	0.936

Potential ligand/drug binding sites

No binding sites identified

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

Chemical Name	Confidence score	Molecular Weight
sulfatePubChem	0.933	96.0626
thiosulfatePubChem	0.93	112.128
cyanidePubChem	0.929	27.0253
glycerolPubChem	0.926	92.0938
hydron sulfatePubChem	0.926	196.157
thiocyanatePubChem	0.922	59.0903
bisulfitePubChem	0.905	80.0632
protiumPubChem	0.9	2.01576
H(+)PubChem	0.9	2.01588
deuteriumPubChem	0.9	2.01588