Rv3175

Tuberculist information
Gene nameRv3175
Protein functionPossible amidase (aminohydrolase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3542.86
Molecular mass(da)52081.9
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 495
	  		  	1    MAMSAKASDDIAWLPATAQLAVLAAKKVSSAELVELYLSRIDTYNASLNAIVTVDPDAAR   60
			  	61   RVAKRSDAARARGDELGPLHGLPITVKDSYETAGMRTTCGRRDLADYVPTQDAEAVARLR  120
			  	121  RAGAIIMGKTNMPTGNQDVQASNPVFGRTNNPWDAARTSGGSAGGGAAATAAGLTSFDYG  180
			  	181  SEIGGSTRIPAHYCGLYGHKSTWRSVPLVGHIPSAPGNPGRWGQADMACAGVQVRGARDI  240
			  	241  IPALEATVGPMRADGGFSYALAPPRAGALKDFRVAVWAEDPHCPIDADVRRAMDDAVAAL  300
			  	301  RAAGAHVVEQPATIPVDMAVSHNIFQSLVFGAFAVDRSTLSPASAAALGLRAVRHPRGEA  360
			  	361  ANALGATLQSHRAWLFADAARHEMRDRWAGFFNEFDVLLLPVTPTPAPLHHNKDHDRLGR  420
			  	421  TIDVDGVSRSYWDQLKWNALANIAGTPATTMPITTTATGLPIGIQAMGPAGGDRTTVEFA  480
			  	481  ALLTEVLGGFRVPPL

Known structures in the PDB
No Known structures
1 50 99 148 197 246 295 344 393 442 491 Range: 32 to 477  |  Coverage: 89% Amidase Range: 8 to 493  |  Coverage: 97% 1 Range: 1 to 495  |  Coverage: 99% 1
Number of amino acids : 495
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
AmidasePF0142532-477
Mtb Structural Proteome models
Model Number1
Model nameRv3175
Template1M22    APDBCREDO
Template coverage42_527
Template Identity(%)26.3
Model coverage(%)98.0
Normalized DOPE score0.387

Structure Models from Chopin
Model Number1
Profilec.117.1.1 - 3.90.1300.10
Click for model details
zscore52.81
Residue begin1
Residue end495
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3175Gene nameConfidence Score
Rv1908ckatG0.907
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
auxinPubChem0.903174.176
benzeneacetamidePubChem0.9135.163
benzoic acidPubChem0.9121.113