Rv3132c

Tuberculist information
Gene namedevS
Protein functionTwo component sensor histidine kinase DevS
Functional category(tuberculist)regulatory proteins
Gene location(kb)3497.53
Molecular mass(da)62240.6
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 578
	  		  	1    MTTGGLVDENDGAAMRPLRHTLSQLRLHELLVEVQDRVEQIVEGRDRLDGLVEAMLVVTA   60
			  	61   GLDLEATLRAIVHSATSLVDARYGAMEVHDRQHRVLHFVYEGIDEETVRRIGHLPKGLGV  120
			  	121  IGLLIEDPKPLRLDDVSAHPASIGFPPYHPPMRTFLGVPVRVRDESFGTLYLTDKTNGQP  180
			  	181  FSDDDEVLVQALAAAAGIAVANARLYQQAKARQSWIEATRDIATELLSGTEPATVFRLVA  240
			  	241  AEALKLTAADAALVAVPVDEDMPAADVGELLVIETVGSAVASIVGRTIPVAGAVLREVFV  300
			  	301  NGIPRRVDRVDLEGLDELADAGPALLLPLRARGTVAGVVVVLSQGGPGAFTDEQLEMMAA  360
			  	361  FADQAALAWQLATSQRRMRELDVLTDRDRIARDLHDHVIQRLFAIGLALQGAVPHERNPE  420
			  	421  VQQRLSDVVDDLQDVIQEIRTTIYDLHGASQGITRLRQRIDAAVAQFADSGLRTSVQFVG  480
			  	481  PLSVVDSALADQAEAVVREAVSNAVRHAKASTLTVRVKVDDDLCIEVTDNGRGLPDEFTG  540
			  	541  SGLTNLRQRAEQAGGEFTLASVPGASGTVLRWSAPLSQ

Known structures in the PDB
PDB ID2W3D
Total residue count306
Number of chains2
MethodX-RAY
Resolution2
PDB ID2W3E
Total residue count306
Number of chains2
MethodX-RAY
Resolution1.6
PDB ID2W3F
Total residue count306
Number of chains2
MethodX-RAY
Resolution1.6
PDB ID2W3G
Total residue count306
Number of chains2
MethodX-RAY
Resolution1.4
PDB ID2W3H
Total residue count306
Number of chains2
MethodX-RAY
Resolution1.8
PDB ID2Y79
Total residue count306
Number of chains2
MethodX-RAY
Resolution1.8
PDB ID2Y8H
Total residue count306
Number of chains2
MethodX-RAY
Resolution1.9
PDB ID3ZXO
Total residue count258
Number of chains2
MethodX-RAY
Resolution1.9
1 58 115 172 229 286 343 400 457 514 571 Range: 63 to 200  |  Coverage: 23% GAF Range: 231 to 369  |  Coverage: 23% GAF Range: 386 to 452  |  Coverage: 11% HisKA_3 Range: 488 to 577  |  Coverage: 15% HATPase_c Range: 58 to 207  |  Coverage: 25% 1 Range: 453 to 575  |  Coverage: 21% 2 Range: 411 to 577  |  Coverage: 28% 3 Range: 47 to 214  |  Coverage: 28% 4 Range: 488 to 577  |  Coverage: 15% 1 Range: 1 to 138  |  Coverage: 23% 2 Range: 63 to 200  |  Coverage: 23% 3 Range: 231 to 368  |  Coverage: 23% 4
Number of amino acids : 578
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
GAFPF0159063-200
GAFPF01590231-369
HisKA_3PF07730386-452
HATPase_cPF02518488-577
Mtb Structural Proteome models
Model Number1
Model nameRv3132c_2w3g_A
Template2W3G    APDBCREDO
Template coverage58_207
Template Identity(%)100.0
Model coverage(%)25.8
Normalized DOPE score-1.886

Model Number2
Model nameRv3132c.3
Template1YSR    APDBCREDO
Template coverage303_443
Template Identity(%)26.0
Model coverage(%)21.1
Normalized DOPE score-1.311

Model Number3
Model nameRv3132c.2
Template1B3Q    APDBCREDO
Template coverage322_540
Template Identity(%)18.6
Model coverage(%)28.7
Normalized DOPE score-0.427

Model Number4
Model nameRv3132c
Template1MC0    APDBCREDO
Template coverage385_555
Template Identity(%)24.4
Model coverage(%)28.9
Normalized DOPE score-0.241

Structure Models from Chopin
Model Number1
Profiled.122.1.3 - 3.30.565.10
Click for model details
zscore13.38
Residue begin488
Residue end577
Model Number2
Profiled.110.2.1 - 3.30.450.40
Click for model details
zscore9.99
Residue begin1
Residue end138
Model Number3
Profiled.110.2.1 - 3.30.450.40
Click for model details
zscore9.99
Residue begin63
Residue end200
Model Number4
Profiled.110.2.1 - 3.30.450.40
Click for model details
zscore9.99
Residue begin231
Residue end368
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3132cGene nameConfidence Score
Rv3133cdevR0.999
Rv3133cdevR0.999
Rv3134cRv3134c0.971
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
selenomethioninePubChem0.944196.106
SeMetPubChem0.927196.106
calciumPubChem0.90540.078
cyanidePubChem0.927.0253