Rv2888c

Tuberculist information
Gene nameamiC
Protein functionProbable amidase AmiC (aminohydrolase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3196.86
Molecular mass(da)50916.1
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 473
	  		  	1    MSRVHAFVDDALGDLDAVALADAIRSGRVGRADVVEAAIARAEAVNPALNALAYAAFDVA   60
			  	61   RDAAAMGTGQEAFFSGVPTFIKDNVDVAGQPSMHGTDAWEPYAAVADSEITRVVLGTGLV  120
			  	121  SLGKTQLSEFGFSAVAEHPRLGPVRNPWNTDYTAGASSSGSGALVAAGVVPIAHANDGGG  180
			  	181  SIRIPAACNGLVGLKPSRGRLPLEPEYRRLPVGIVANGVLTRTVRDTAAFYREAERLWRN  240
			  	241  HQLPPVGDVTSPVKQRLRIAVVTRSVLREASPEVRQLTLKLAGLLEELGHRVEHVDHPPA  300
			  	301  PASFVDDFVLYWGFLALAQVRSGRRTFGRTFDPTRLDELTLGLARHTGRNLHRLPLAIMR  360
			  	361  LRMLRRRSVRFFGTYDVLLTPTVAEATPQVGYLAPTDYQTVLDRLSSWVVFTPVQNVTGV  420
			  	421  PAISLPLAQSADGMPVGMMLSADTGREALLLELAYELEEARPWARIHAPNIAE

Known structures in the PDB
No Known structures
1 48 95 142 189 236 283 330 377 424 471 Range: 33 to 451  |  Coverage: 88% Amidase Range: 11 to 470  |  Coverage: 97% 1 Range: 1 to 473  |  Coverage: 99% 1
Number of amino acids : 473
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
AmidasePF0142533-451
Mtb Structural Proteome models
Model Number1
Model nameRv2888c
Template1M22    APDBCREDO
Template coverage44_528
Template Identity(%)25.4
Model coverage(%)97.0
Normalized DOPE score0.119

Structure Models from Chopin
Model Number1
Profilec.117.1.1 - 3.90.1300.10
Click for model details
zscore48.72
Residue begin1
Residue end473
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2888cGene nameConfidence Score
Rv1908ckatG0.902
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
auxinPubChem0.904174.176
benzeneacetamidePubChem0.9135.163
benzoic acidPubChem0.9121.113