Rv2779c

Tuberculist information
Gene nameRv2779c
Protein functionPossible transcriptional regulatory protein (probably Lrp/AsnC-family)
Functional category(tuberculist)regulatory proteins
Gene location(kb)3086.22
Molecular mass(da)19871.8
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 179
	  		  	1    MIILFRGHMRDNSTEHKTRRAASSKDVRPAELDEVDRRILSLLHGDARMPNNALADTVGI   60
			  	61   APSTCHGRVRRLVDLGVIRGFYTDIDPVAVGLPLQAMISVNLQSSARGKIRSFIQQIRRK  120
			  	121  RQVMDVYFLAGADDFILHVAARDTEDLRSFVVENLNADADVAGTQTSLIFEHLRGAAPI

Known structures in the PDB
No Known structures
1 18 35 52 69 86 103 120 137 154 171 Range: 32 to 73  |  Coverage: 22% HTH_AsnC-type Range: 98 to 172  |  Coverage: 41% AsnC_trans_reg Range: 32 to 171  |  Coverage: 77% 1 Range: 31 to 179  |  Coverage: 82% 1 Range: 30 to 93  |  Coverage: 35% 2 Range: 83 to 179  |  Coverage: 53% 3 Range: 15 to 121  |  Coverage: 59% 4
Number of amino acids : 179
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
HTH_AsnC-typePF1340432-73
AsnC_trans_regPF0103798-172
Mtb Structural Proteome models
Model Number1
Model nameRv2779c
Template1RI7    APDBCREDO
Template coverage25_160
Template Identity(%)30.1
Model coverage(%)77.7
Normalized DOPE score-0.186

Structure Models from Chopin
Model Number1
Profile1.10.10.10, 3.30.70.920
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zscore33.39
Residue begin31
Residue end179
Model Number2
Profilea.4.5.32
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zscore20.46
Residue begin30
Residue end93
Model Number3
Profile3.30.70.920
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zscore17.83
Residue begin83
Residue end179
Model Number4
Profilea.4.5.50 - 1.10.10.10
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zscore8.56
Residue begin15
Residue end121
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2779cGene nameConfidence Score
Rv2780ald0.902
Rv2780ald0.902
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions