Rv2363

Tuberculist information
Gene nameamiA2
Protein functionProbable amidase AmiA2 (aminohydrolase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2644.32
Molecular mass(da)50851.7
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 484
	  		  	1    VVGASGSDAGAISGSGNQRLPTLTDLLYQLATRAVTSEELVRRSLRAIDVSQPTLNAFRV   60
			  	61   VLTESALADAAAADKRRAAGDTAPLLGIPIAVKDDVDVAGVPTAFGTQGYVAPATDDCEV  120
			  	121  VRRLKAAGAVIVGKTNTCELGQWPFTSGPGFGHTRNPWSRRHTPGGSSGGSAAAVAAGLV  180
			  	181  TAAIGSDGAGSIRIPAAWTHLVGIKPQRGRISTWPLPEAFNGVTVNGVLARTVEDAALVL  240
			  	241  DAASGNVEGDRHQPPPVTVSDFVGIAPGPLKIALSTHFPYTGFRAKLHPEILAATQRVGD  300
			  	301  QLELLGHTVVKGNPDYGLRLSWNFLARSTAGLWEWAERLGDEVTLDRRTVSNLRMGHVLS  360
			  	361  QAILRSARRHEAADQRRVGSIFDIVDVVLAPTTAQPPPMARAFDRLGSFGTDRAIIAACP  420
			  	421  STWPWNLLGWPSINVPAGFTSDGLPIGVQLMGPANSEGMLISLAAELEAVSGWATKQPQV  480
			  	481  WWTS

Known structures in the PDB
No Known structures
1 49 97 145 193 241 289 337 385 433 481 Range: 39 to 461  |  Coverage: 87% Amidase Range: 20 to 471  |  Coverage: 93% 1 Range: 1 to 484  |  Coverage: 99% 1
Number of amino acids : 484
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
AmidasePF0142539-461
Mtb Structural Proteome models
Model Number1
Model nameRv2363
Template1OCK    APDBCREDO
Template coverage1_410
Template Identity(%)29.8
Model coverage(%)93.2
Normalized DOPE score-0.277

Structure Models from Chopin
Model Number1
Profilec.117.1.1 - 3.90.1300.10
Click for model details
zscore48.82
Residue begin1
Residue end484
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2363Gene nameConfidence Score
Rv1908ckatG0.91
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
auxinPubChem0.906174.176
benzeneacetamidePubChem0.9135.163
benzoic acidPubChem0.9121.113