Rv1854c

Tuberculist information
Gene namendh
Protein functionProbable NADH dehydrogenase Ndh
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2101.65
Molecular mass(da)49619
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 463
	  		  	1    MSPQQEPTAQPPRRHRVVIIGSGFGGLNAAKKLKRADVDIKLIARTTHHLFQPLLYQVAT   60
			  	61   GIISEGEIAPPTRVVLRKQRNVQVLLGNVTHIDLAGQCVVSELLGHTYQTPYDSLIVAAG  120
			  	121  AGQSYFGNDHFAEFAPGMKSIDDALELRGRILSAFEQAERSSDPERRAKLLTFTVVGAGP  180
			  	181  TGVEMAGQIAELAEHTLKGAFRHIDSTKARVILLDAAPAVLPPMGAKLGQRAAARLQKLG  240
			  	241  VEIQLGAMVTDVDRNGITVKDSDGTVRRIESACKVWSAGVSASRLGRDLAEQSRVELDRA  300
			  	301  GRVQVLPDLSIPGYPNVFVVGDMAAVEGVPGVAQGAIQGAKYVASTIKAELAGANPAERE  360
			  	361  PFQYFDKGSMATVSRFSAVAKIGPVEFSGFIAWLIWLVLHLAYLIGFKTKITTLLSWTVT  420
			  	421  FLSTRRGQLTITDQQAFARTRLEQLAELAAEAQGSAASAKVAS

Known structures in the PDB
No Known structures
1 47 93 139 185 231 277 323 369 415 461 Range: 16 to 328  |  Coverage: 67% Pyr_redox_2 Range: 16 to 463  |  Coverage: 96% 1 Range: 13 to 220  |  Coverage: 44% 1
Number of amino acids : 463
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Pyr_redox_2PF0799216-328
Mtb Structural Proteome models
Model Number1
Model nameRv1854c
Template1Q1R    APDBCREDO
Template coverage6_421
Template Identity(%)20.0
Model coverage(%)96.5
Normalized DOPE score0.957

Structure Models from Chopin
Model Number1
Profilec.3.1.7
Click for model details
zscore8.39
Residue begin13
Residue end220
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1854cGene nameConfidence Score
Rv1908ckatG0.922
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
NAD+PubChem0.96663.425
reduced nicotinamide adenine dinucleotidePubChem0.931665.441
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
isoniazidPubChem0.731137.139
ethionamidePubChem0.701166.243