Rv1395

Tuberculist information
Gene nameRv1395
Protein functionTranscriptional regulatory protein
Functional category(tuberculist)regulatory proteins
Gene location(kb)1571.05
Molecular mass(da)37862.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 344
	  		  	1    VGHLPPPAEVRHPVYATRVLCEVANERGVPTADVLAGTAIEPADLDDPDAVVGALDEITA   60
			  	61   VRRLLARLPDDAGIGIDVGSRFALTHFGLFGFAVMSCGTLRELLTIAMRYFALTTMHVDI  120
			  	121  TLFETADDCLVELDASHLPADVRGFFIERDIAGIIATTTSFALPLAAKYADQVSAELAVD  180
			  	181  AELLRPLLELVPVHDVAFGRAHNRVHFPRAMFDEPLPQADRHTLEMCIAQCDVLMQRNER  240
			  	241  RRGITALVRSKLFRDSGLFPTFTDVAGELDMHPRTLRRRLAEEGTSFRALLGEARSTVAV  300
			  	301  DLLRNVGLTVQQVSTRLGYTEVSTFSHAFKRWYGVAPSEYSRRG

Known structures in the PDB
No Known structures
1 35 69 103 137 171 205 239 273 307 341 Range: 28 to 216  |  Coverage: 54% Arabinose_bd Range: 265 to 343  |  Coverage: 22% HTH_18 Range: 241 to 342  |  Coverage: 29% 1 Range: 291 to 344  |  Coverage: 15% 1 Range: 196 to 289  |  Coverage: 27% 2
Number of amino acids : 344
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Arabinose_bdPF1262528-216
HTH_18PF12833265-343
Mtb Structural Proteome models
Model Number1
Model nameRv1395
Template1D5Y    APDBCREDO
Template coverage3_105
Template Identity(%)19.6
Model coverage(%)29.4
Normalized DOPE score-0.891

Structure Models from Chopin
Model Number1
Profilea.4.1.8
Click for model details
zscore9.9
Residue begin291
Residue end344
Model Number2
Profilea.4.1.12 - 1.10.10.60
Click for model details
zscore4.72
Residue begin196
Residue end289
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1395Gene nameConfidence Score
Rv1393cRv1393c0.902
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Target nameCHEMBL IDSMILES
ToxTOC(=O)CCCN3C(=O)C1=CC=CC2=CC=CC(=C12)C3=O
STITCH interactions  
No high confidence interactions