Rv1267c

Tuberculist information
Gene nameembR
Protein functionProbable transcriptional regulatory protein EmbR
Functional category(tuberculist)regulatory proteins
Gene location(kb)1416.18
Molecular mass(da)41933.5
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 388
	  		  	1    MAGSATVEKRLDFGLLGPLQMTIDGTPVPSGTPKQRAVLAMLVINRNRPVGVDALITALW   60
			  	61   EEWPPSGARASIHSYVSNLRKLLGGAGIDPRVVLAAAPPGYRLSIPDNTCDLGRFVAEKT  120
			  	121  AGVHAAAAGRFEQASRHLSAALREWRGPVLDDLRDFQFVEPFATALVEDKVLAHTAKAEA  180
			  	181  EIACGRASAVIAELEALTFEHPYREPLWTQLITAYYLSDRQSDALGAYRRVKTTLADDLG  240
			  	241  IDPGPTLRALNERILRQQPLDAKKSAKTTAAGTVTVLDQRTMASGQQAVAYLHDIASGRG  300
			  	301  YPLQAAATRIGRLHDNDIVLDSANVSRHHAVIVDTGTNYVINDLRSSNGVHVQHERIRSA  360
			  	361  VTLNDGDHIRICDHEFTFQISAGTHGGT

Known structures in the PDB
PDB ID2FEZ
Total residue count388
Number of chains1
MethodX-RAY
Resolution2
PDB ID2FF4
Total residue count794
Number of chains4
MethodX-RAY
Resolution1.9
1 39 77 115 153 191 229 267 305 343 381 Range: 25 to 103  |  Coverage: 20% Trans_reg_C Range: 110 to 255  |  Coverage: 37% BTAD Range: 308 to 372  |  Coverage: 16% FHA Range: 8 to 386  |  Coverage: 97% 1 Range: 8 to 386  |  Coverage: 97% 2 Range: 8 to 386  |  Coverage: 97% 1 Range: 105 to 283  |  Coverage: 45% 2 Range: 308 to 372  |  Coverage: 16% 3 Range: 25 to 103  |  Coverage: 20% 4
Number of amino acids : 388
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Trans_reg_CPF0048625-103
BTADPF03704110-255
FHAPF00498308-372
Mtb Structural Proteome models
Model Number1
Model nameRv1267c_2ff4_A
Template2FF4    APDBCREDO
Template coverage8_386
Template Identity(%)100.0
Model coverage(%)97.4
Normalized DOPE score-1.595

Model Number2
Model nameRv1267c
Template2FF4    APDBCREDO
Template coverage8_386
Template Identity(%)100.0
Model coverage(%)97.4
Normalized DOPE score-1.263

Structure Models from Chopin
Model Number1
Profilea.118.8.3, a.4.6.1, b.26.1.2
Click for model details
zscore56.96
Residue begin8
Residue end386
Model Number2
Profilea.118.8.3
Click for model details
zscore37.3
Residue begin105
Residue end283
Model Number3
Profileb.26.1.2 - 2.60.200.20
Click for model details
zscore14.57
Residue begin308
Residue end372
Model Number4
Profilea.4.6.1 - 1.10.10.10
Click for model details
zscore11.62
Residue begin25
Residue end103
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1267cGene nameConfidence Score
Rv1266cpknH0.986
Rv1266cpknH0.986
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
O-phospho-L-threoninePubChem0.9199.099