Rv1263

Tuberculist information
Gene nameamiB2
Protein functionProbable amidase AmiB2 (aminohydrolase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1410.43
Molecular mass(da)49048.9
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 462
	  		  	1    VDPTDLAFAGAAAQARMLADGALTAPMLLEVYLQRIERLDSHLRAYRVVQFDRARAEAEA   60
			  	61   AQQRLDAGERLPLLGVPIAIKDDVDIAGEVTTYGSAGHGPAATSDAEVVRRLRAAGAVII  120
			  	121  GKTNVPELMIMPFTESLAFGATRNPWCLNRTPGGSSGGSAAAVAAGLAPVALGSDGGGSI  180
			  	181  RIPCTWCGLFGLKPQRDRISLEPHDGAWQGLSVNGPIARSVMDAALLLDATTTVPGPEGE  240
			  	241  FVAAAARQPGRLRIALSTRVPTPLPVRCGKQELAAVHQAGALLRDLGHDVVVRDPDYPAS  300
			  	301  TYANYLPRFFRGISDDADAQAHPDRLEARTRAIARLGSFFSDRRMAALRAAEVVLSSRIQ  360
			  	361  SIFDDVDVVVTPGAATGPSRIGAYQRRGAVSTLLLVVQRVPYFQVWNLTGQPAAVVPWDF  420
			  	421  DGDGLPMSVQLVGRPYDEATLLALAAQIESARPWAHRRPSVS

Known structures in the PDB
No Known structures
1 47 93 139 185 231 277 323 369 415 461 Range: 27 to 442  |  Coverage: 89% Amidase Range: 3 to 460  |  Coverage: 98% 1 Range: 1 to 462  |  Coverage: 99% 1
Number of amino acids : 462
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
AmidasePF0142527-442
Mtb Structural Proteome models
Model Number1
Model nameRv1263
Template1M22    APDBCREDO
Template coverage42_527
Template Identity(%)29.5
Model coverage(%)98.9
Normalized DOPE score0.36

Structure Models from Chopin
Model Number1
Profilec.117.1.1 - 3.90.1300.10
Click for model details
zscore41.15
Residue begin1
Residue end462
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1263Gene nameConfidence Score
Rv1908ckatG0.907
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
auxinPubChem0.905174.176
benzeneacetamidePubChem0.9135.163
benzoic acidPubChem0.9121.113