Tuberculist information
Gene nameRv1084
Protein functionConserved protein
Functional category(tuberculist)conserved hypotheticals
Gene location(kb)1207.64
Molecular mass(da)71050.3
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 673
	  		  	1    MSPANPSGTNTLALATSPYLRQHADNPVHWQQWTPQALAEAAARAVPILLSVGYAACHWC   60
			  	61   HVMAHESFDDDEVAAAMNAGFVCIKVDREERPDIDAVYMNATVALTGQGGWPMTCFLTPN  120
			  	121  GRPFFCGTYYPKAAFLQLLSAISETWRERRAEVEQASDHIAAELRSMASGLPGGGPEVAP  180
			  	181  ELCDDAVAGVLREQDTAHGGFGGAPKFPPSALLEALMRHYERTRSPAALEAVARTGNAMA  240
			  	241  RGGIYDQLGGGFARYSVDGAWVVPHFEKMLYDNALLLRAYAHWARRTGDPLARRVAAQTA  300
			  	301  RFLLDELGSKAPADMFTSSLDADADGREGSTYVWTPVQLTEVLGGDDGRWAAEVFGVTEA  360
			  	361  GTFEHGTSVLQLPADPDDAARLDRVRAALLVARLARAQPARDDKVVTSWNGLAITALAEA  420
			  	421  SVALDDPALAHAARRCATRLLDLHVVDGRLRRASLGGVVGDSAAILEDHAMLATGLLALY  480
			  	481  QLTSEGAWLTAATGLLDTAVAHFGDPQRPGRWFDTADDAERLMLRPSDPLDGATPSGASS  540
			  	541  IAEALLTAGHVVDGARAERYWQLAADTLRAHAVLLARAPRSAGHWLAVAEAVVRGPLQIA  600
			  	601  VACDLPRSSLLADARRLAPGGAIVVGGAAGSSALLVGRDRVAGADAAYVCRGRVCDLPVT  660
			  	661  SAAELATALGVPG
			  			

Known structures in the PDB
No Known structures
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Thioredox_DsbHPF031909-165
GlcNAc_2-epimPF07221219-518
Mtb Structural Proteome models
Model Number1
Model nameRv1084.1
Template1EP7    APDBCREDO
Template coverage13_112
Template Identity(%)14.0
Model coverage(%)16.5
Normalized DOPE score-0.041

Model Number2
Model nameRv1084.2
Template2CVK    APDBCREDO
Template coverage9_105
Template Identity(%)16.5
Model coverage(%)15.9
Normalized DOPE score0.136

Model Number3
Model nameRv1084
Template2FV1    APDBCREDO
Template coverage2_346
Template Identity(%)15.7
Model coverage(%)56.2
Normalized DOPE score0.529

Model Number4
Model nameRv1084.4
Template2AFA    APDBCREDO
Template coverage7_408
Template Identity(%)9.8
Model coverage(%)61.8
Normalized DOPE score1.045

Structure Models from Chopin
Model Number1
Profilec.47.1.24
Click for model details
zscore6.91
Residue begin9
Residue end160
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1084Gene nameConfidence Score
Rv1083Rv10830.984
Rv1082mca0.977
Potential ligand/drug binding sites
Protein ModelPocket NumberDrug Binding Site PMIN ScorePvalue PMINPMAX ScorePvalue PMAX
Rv1084.213ri5_IVM_E_349PDBCREDO0.6900.0880.6900.000
Rv1084.213ri5_IVM_B_349PDBCREDO0.7370.0550.6820.000
Rv1084.213rif_IVM_E_402PDBCREDO0.7340.0570.6790.000
Rv1084.213ri5_IVM_D_349PDBCREDO0.7320.0590.6770.000
Rv1084.213rhw_IVM_B_349PDBCREDO0.7300.0600.6760.000
Rv1084.213rhw_IVM_D_348PDBCREDO0.7290.0600.6750.000
Rv1084.213ri5_IVM_A_349PDBCREDO0.7290.0600.6750.000
Rv1084.213rhw_IVM_B_348PDBCREDO0.7290.0610.6740.000
Rv1084.213ria_IVM_A_348PDBCREDO0.7290.0610.6740.000
Rv1084.213ria_IVM_C_350PDBCREDO0.7280.0610.6730.000
Rv1084.213ria_IVM_E_349PDBCREDO0.7270.0620.6730.000
Rv1084.213rhw_IVM_D_349PDBCREDO0.7250.0630.6710.000
Rv1084.213ria_IVM_E_348PDBCREDO0.7220.0650.6680.001
Rv1084.213rhw_IVM_A_348PDBCREDO0.7220.0650.6680.001
Rv1084.211ict_T44_D_129PDBCREDO0.6350.1390.6350.001
Rv1084.213sxr_1N1_A_1PDBCREDO0.6330.1420.6330.001
Rv1084.213rif_IVM_A_402PDBCREDO0.7640.0400.6320.001
Rv1084.213rif_IVM_D_402PDBCREDO0.7640.0400.6320.001
Rv1084.213rif_IVM_B_403PDBCREDO0.7620.0420.6310.001
Rv1084.213ri5_IVM_C_350PDBCREDO0.7610.0420.6300.001
Rv1084.213ria_IVM_C_349PDBCREDO0.7570.0440.6270.001
Rv1084.211ya3_STR_C_3001PDBCREDO0.7290.0610.6260.001
Rv1084.213rif_IVM_A_403PDBCREDO0.7490.0480.6200.001
Rv1084.213adx_IMN_B_3PDBCREDO0.6420.1320.6170.002
Rv1084.213sxr_1N1_B_2PDBCREDO0.6360.1390.6110.002
Rv1084.211ya3_STR_B_2001PDBCREDO0.7850.0310.6060.002
Rv1084.123a2q_ACA_A_601PDBCREDO0.6010.1780.6010.002
Rv1084.211jip_KTN_A_801PDBCREDO0.6510.1240.6000.002
Rv1084.212w8y_NDR_B_1000PDBCREDO0.5950.1860.5950.002
Rv1084.211ya3_STR_A_1001PDBCREDO0.7650.0400.5900.003
Rv1084.211jg3_ADN_B_550PDBCREDO0.6120.1650.5880.003
Rv1084.211ict_T44_C_128PDBCREDO0.6370.1380.5870.003
Rv1084.123ijx_HCZ_D_800PDBCREDO0.6600.1150.5870.003
Rv1084.212o7o_DXT_A_222PDBCREDO0.6100.1670.5860.003
Rv1084.213bbt_FMM_B_91PDBCREDO0.6300.1450.5830.003
Rv1084.212xpw_OTC_A_222PDBCREDO0.6050.1730.5810.003
Rv1084.211jin_KTN_A_801PDBCREDO0.5790.2050.5790.003
Rv1084.212trt_TAC_A_222PDBCREDO0.6020.1760.5790.003
Rv1084.213h52_486_C_4PDBCREDO0.6980.0820.5780.003
Rv1084.212vke_TAC_A_222PDBCREDO0.5990.1800.5760.003
Rv1084.212aa5_STR_A_301PDBCREDO0.8260.0160.5750.003
Rv1084.211p93_DEX_A_1999PDBCREDO0.7690.0380.5730.003
Rv1084.211jg3_ADN_A_500PDBCREDO0.6660.1090.5720.003
Rv1084.212aa5_STR_B_302PDBCREDO0.8190.0180.5700.004
Rv1084.211p93_DEX_B_2999PDBCREDO0.7650.0400.5700.004
Rv1084.212xpv_MIY_A_1209PDBCREDO0.7140.0710.5700.004
Rv1084.212aax_PDN_A_502PDBCREDO0.8120.0210.5660.004
Rv1084.212aax_PDN_B_503PDBCREDO0.8120.0210.5660.004
Rv1084.213ls4_TCI_H_220PDBCREDO0.5650.2230.5650.004
Rv1084.212ity_IRE_A_2020PDBCREDO0.5650.2240.5650.004
Rv1084.212w9s_TOP_D_1158PDBCREDO0.6370.1370.5640.004
Rv1084.212q1v_PDN_A_248PDBCREDO0.7290.0600.5630.004
Rv1084.212h42_VIA_B_902PDBCREDO0.6790.0980.5620.004
Rv1084.212h42_VIA_C_903PDBCREDO0.6790.0980.5620.004
Rv1084.212h42_VIA_A_901PDBCREDO0.7540.0460.5620.004
Rv1084.212aa6_STR_A_401PDBCREDO0.8050.0230.5610.004
Rv1084.212xn5_FUN_A_1356PDBCREDO0.5840.1990.5610.004
Rv1084.213ads_IMN_B_3PDBCREDO0.6600.1140.5600.004
Rv1084.211ie4_T44_B_328PDBCREDO0.5820.2010.5600.004
Rv1084.212aa6_STR_B_402PDBCREDO0.8020.0240.5590.004
Rv1084.212ito_IRE_A_2020PDBCREDO0.6030.1750.5580.004
Rv1084.212itz_IRE_A_2021PDBCREDO0.5800.2030.5580.004
Rv1084.212uxo_TAC_B_1211PDBCREDO0.5800.2030.5580.004
Rv1084.211ya4_CTX_C_3PDBCREDO0.5550.2370.5550.005
Rv1084.213jwq_VIA_B_901PDBCREDO0.6710.1050.5550.005
Rv1084.211ya4_CTX_B_2PDBCREDO0.5520.2410.5520.005
Rv1084.423el4_ROC_A_100PDBCREDO0.6470.1280.5520.005
Rv1084.211a28_STR_A_1PDBCREDO0.6890.0890.5510.005
Rv1084.213q1e_T44_C_128PDBCREDO0.5940.1870.5490.005
Rv1084.213bbt_FMM_D_91PDBCREDO0.7350.0570.5480.005
Rv1084.211mx1_THA_F_6PDBCREDO0.5470.2490.5470.005
Rv1084.211mx1_THA_D_4PDBCREDO0.5450.2510.5450.005
Rv1084.212ab2_SNL_B_503PDBCREDO0.8600.0080.5440.006
Rv1084.211jg2_ADN_A_500PDBCREDO0.7050.0770.5440.006
Rv1084.212ab2_SNL_A_502PDBCREDO0.8600.0090.5440.006
Rv1084.111lhu_EST_A_301PDBCREDO0.5780.2060.5380.006
Rv1084.123o0q_ADN_B_1004PDBCREDO0.6380.1360.5380.006
Rv1084.113hku_TOR_A_300PDBCREDO0.5370.2620.5370.006
Rv1084.421t7i_017_A_200PDBCREDO0.6290.1460.5370.006
Rv1084.212oax_SNL_C_3001PDBCREDO0.8490.0110.5370.006
Rv1084.421k6c_MK1_B_902PDBCREDO0.6280.1470.5360.006
Rv1084.123re0_CPT_B_201PDBCREDO0.6900.0890.5350.006
Rv1084.213aod_RFP_C_2002PDBCREDO0.6230.1530.5350.006
Rv1084.213vhu_SNL_A_1001PDBCREDO0.8450.0120.5340.006
Rv1084.213gn8_DEX_B_247PDBCREDO0.7920.0280.5340.006
Rv1084.213jwq_VIA_D_901PDBCREDO0.7150.0700.5320.007
Rv1084.213gn8_DEX_A_247PDBCREDO0.7880.0290.5310.007
Rv1084.111ya3_STR_C_3001PDBCREDO0.5310.2710.5310.007
Rv1084.211p93_DEX_C_3999PDBCREDO0.7870.0300.5300.007
Rv1084.213mne_DEX_A_784PDBCREDO0.7870.0300.5300.007
Rv1084.121lik_ADN_A_799PDBCREDO0.5610.2280.5290.007
Rv1084.111fr6_AZR_B_362PDBCREDO0.5690.2180.5280.007
Rv1084.211p93_DEX_D_4999PDBCREDO0.7820.0320.5270.007
Rv1084.112xpv_MIY_A_1209PDBCREDO0.5660.2220.5270.007
Rv1084.132cbr_A80_A_201PDBCREDO0.5470.2480.5270.007
Rv1084.211m2z_DEX_D_401PDBCREDO0.7810.0320.5270.007
Rv1084.211nhz_486_A_800PDBCREDO0.7310.0590.5270.007
Rv1084.223g0e_B49_A_9000PDBCREDO0.5480.2460.5270.007
Rv1084.212oax_SNL_B_2001PDBCREDO0.8320.0150.5260.007
Rv1084.211ie4_T44_A_128PDBCREDO0.5710.2160.5260.007
Rv1084.211mrl_DOL_A_300PDBCREDO0.5950.1850.5260.007
Rv1084.113jwq_VIA_B_901PDBCREDO0.5450.2500.5260.007
Rv1084.211mx1_THA_C_3PDBCREDO0.6580.1170.5260.007
Rv1084.123o0q_ADN_A_1004PDBCREDO0.6240.1520.5260.007
Rv1084.213kw2_ADN_B_300PDBCREDO0.5250.2790.5250.007
Rv1084.213q1e_T44_D_328PDBCREDO0.6200.1560.5250.007
Rv1084.213f4x_KLT_A_300PDBCREDO0.5680.2200.5250.007
Rv1084.112h42_VIA_C_903PDBCREDO0.5450.2510.5250.007
Rv1084.421c6z_ROC_B_505PDBCREDO0.6780.0990.5250.007
Rv1084.211m2z_DEX_A_301PDBCREDO0.7770.0340.5240.008
Rv1084.212xn6_T44_A_1370PDBCREDO0.5450.2510.5240.008
Rv1084.211uho_VDN_A_1000PDBCREDO0.5910.1900.5230.008
Rv1084.112h42_VIA_B_902PDBCREDO0.5420.2550.5230.008
Rv1084.211mx1_THA_A_1PDBCREDO0.5900.1910.5220.008
Rv1084.211udu_CIA_B_2003PDBCREDO0.6160.1600.5220.008
Rv1084.113g0e_B49_A_9000PDBCREDO0.6330.1420.5220.008
Rv1084.211a27_EST_A_350PDBCREDO0.5430.2540.5220.008
Rv1084.223fuu_ADN_A_0PDBCREDO0.5880.1940.5210.008
Rv1084.213cs8_BRL_A_503PDBCREDO0.5210.2860.5210.008
Rv1084.421c6y_MK1_B_524PDBCREDO0.7850.0310.5200.008
Rv1084.114e3a_ADN_B_500PDBCREDO0.5390.2590.5200.008
Rv1084.212xn7_T44_A_1355PDBCREDO0.5400.2580.5190.008
Rv1084.113k2h_LYA_B_514PDBCREDO0.5580.2330.5190.008
Rv1084.113kw2_ADN_A_300PDBCREDO0.5380.2610.5190.008
Rv1084.221v8b_ADN_C_2502PDBCREDO0.5620.2270.5180.008
Rv1084.211sqn_NDR_A_1001PDBCREDO0.6490.1260.5180.008
Rv1084.211sqn_NDR_B_2001PDBCREDO0.6470.1270.5170.008
Rv1084.111oq5_CEL_A_701PDBCREDO0.5360.2640.5170.008
Rv1084.211m17_AQ4_A_999PDBCREDO0.5600.2300.5170.008
Rv1084.111fr6_AZR_A_362PDBCREDO0.5570.2350.5160.008
Rv1084.112aa5_STR_A_301PDBCREDO0.6360.1380.5160.009
Rv1084.133fuu_ADN_A_0PDBCREDO0.5360.2640.5160.009
Rv1084.111ya3_STR_B_2001PDBCREDO0.5740.2120.5150.009
Rv1084.221v8b_ADN_D_3502PDBCREDO0.5370.2620.5150.009
Rv1084.112aa5_STR_B_302PDBCREDO0.6350.1400.5150.009
Rv1084.421rl8_RIT_A_9001PDBCREDO0.6500.1250.5150.009
Rv1084.423oxc_ROC_A_401PDBCREDO0.5270.2780.5150.009
Rv1084.212ij7_TPF_F_2474PDBCREDO0.7260.0620.5150.009
Rv1084.113aod_RFP_C_2002PDBCREDO0.5140.2960.5140.009
Rv1084.221v8b_ADN_B_1502PDBCREDO0.5360.2630.5140.009
Rv1084.422nnp_ROC_A_401PDBCREDO0.6020.1770.5130.009
Rv1084.122wd9_IBP_A_1570PDBCREDO0.5810.2030.5130.009
Rv1084.212xrl_DXT_A_1211PDBCREDO0.6050.1730.5130.009
Rv1084.213k54_1N1_A_1PDBCREDO0.5960.1840.5120.009
Rv1084.213e22_LOC_D_700PDBCREDO0.8090.0220.5110.009
Rv1084.223ubo_ADN_A_353PDBCREDO0.5560.2360.5110.009
Rv1084.213e22_LOC_B_700PDBCREDO0.8080.0220.5110.009
Rv1084.123ijx_HCZ_B_800PDBCREDO0.7090.0740.5100.009
Rv1084.212ayl_FLP_B_2701PDBCREDO0.5530.2400.5100.009
Rv1084.132kce_D16_A_566PDBCREDO0.5090.3050.5090.010
Rv1084.113bl1_BL1_A_300PDBCREDO0.5480.2470.5080.010
Rv1084.113sv9_SV6_A_1PDBCREDO0.5480.2470.5080.010
Rv1084.123h9u_ADN_A_439PDBCREDO0.5400.2580.5080.010
Rv1084.123ozk_T44_A_128PDBCREDO0.5700.2160.5080.010
Rv1084.133k2h_LYA_A_514PDBCREDO0.5270.2770.5070.010
Rv1084.213mnp_DEX_A_784PDBCREDO0.8270.0160.5070.010
Rv1084.112pou_I7A_A_1000PDBCREDO0.5460.2490.5070.010
Rv1084.114eyb_0WO_B_301PDBCREDO0.5070.3070.5070.010
Rv1084.422qak_1UN_A_1001PDBCREDO0.6550.1200.5070.010
Rv1084.223ubo_ADN_B_353PDBCREDO0.5510.2420.5070.010
Rv1084.213mno_DEX_A_784PDBCREDO0.8270.0160.5070.010
Rv1084.113h52_486_C_4PDBCREDO0.5250.2800.5060.010
Rv1084.122x0p_ADN_A_1607PDBCREDO0.5690.2190.5060.010
Rv1084.422q64_1UN_B_1001PDBCREDO0.6540.1210.5060.010
Rv1084.213d90_NOG_A_1001PDBCREDO0.7020.0790.5060.010
Rv1084.422pym_1UN_A_1001PDBCREDO0.6530.1210.5050.010
Rv1084.133nrr_D16_B_530PDBCREDO0.5680.2190.5050.010
Rv1084.211lhu_EST_A_301PDBCREDO0.6320.1430.5050.010
Rv1084.111p93_DEX_A_1999PDBCREDO0.5820.2010.5050.010
Rv1084.423prs_RIT_A_1001PDBCREDO0.6360.1380.5050.010
Rv1084.111i2w_CFX_B_2300PDBCREDO0.6110.1660.5040.010
Rv1084.111zgf_TRU_A_300PDBCREDO0.5440.2530.5040.010
Rv1084.133ti1_B49_A_299PDBCREDO0.5240.2810.5040.010
Rv1084.213r9c_ECL_A_451PDBCREDO0.8680.0070.5040.010
Rv1084.422q63_1UN_A_1001PDBCREDO0.6510.1230.5040.010
Rv1084.422pyn_1UN_A_1001PDBCREDO0.6500.1240.5030.010
Rv1084.123ilu_HFZ_E_800PDBCREDO0.5650.2230.5030.010
Rv1084.111i2w_CFX_A_1300PDBCREDO0.6100.1670.5030.010
Rv1084.113k54_1N1_A_1PDBCREDO0.5030.3140.5030.010
Rv1084.213d90_NOG_B_2001PDBCREDO0.6970.0830.5020.011
Rv1084.111ya3_STR_A_1001PDBCREDO0.5590.2320.5020.011
Rv1084.111p93_DEX_B_2999PDBCREDO0.5780.2060.5020.011
Rv1084.211lhv_NOG_A_301PDBCREDO0.7680.0380.5010.011
Rv1084.133kw2_ADN_A_300PDBCREDO0.5200.2870.5010.011
Rv1084.211z9h_IMN_A_379PDBCREDO0.5900.1910.5000.011
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions