Rv0137c

Tuberculist information
Gene namemsrA
Protein functionProbable peptide methionine sulfoxide reductase MsrA (protein-methionine-S-oxide reductase) (peptide met(O) reductase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)164.712
Molecular mass(da)20484.8
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 182
	  		  	1    MTSNQKAILAGGCFWGLQDLIRNQPGVVSTRVGYSGGNIPNATYRNHGTHAEAVEIIFDP   60
			  	61   TVTDYRTLLEFFFQIHDPTTKDRQGNDRGTSYRSAIFYFDEQQKRIALDTIADVEASGLW  120
			  	121  PGKVVTEVSPAGDFWEAEPEHQDYLQRYPNGYTCHFVRPGWRLPRRTAESALRASLSPEL  180
			  	181  GT

Known structures in the PDB
PDB ID1NWA
Total residue count203
Number of chains1
MethodX-RAY
Resolution1.5
1 19 37 55 73 91 109 127 145 163 181 Range: 5 to 157  |  Coverage: 83% PMSR Range: to 1  |  Coverage: 0% 1 Range: 1 to 166  |  Coverage: 90% 2 Range: 1 to 168  |  Coverage: 91% 1
Number of amino acids : 182
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
PMSRPF016255-157
Mtb Structural Proteome models
Model Number1
Model nameRv0137c_1nwa_A
Template1NWA    APDBCREDO
Template coverage0_166
Template Identity(%)100.0
Model coverage(%)91.2
Normalized DOPE score-2.188

Model Number2
Model nameRv0137c
Template1NWA    APDBCREDO
Template coverage1_166
Template Identity(%)100.0
Model coverage(%)90.7
Normalized DOPE score-1.937

Structure Models from Chopin
Model Number1
Profiled.58.28.1 - 3.30.1060.10
Click for model details
zscore40.05
Residue begin1
Residue end168
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0137cGene nameConfidence Score
Rv2674msrB0.999
Rv3914trxC0.992
Rv0139Rv01390.937
Rv3846sodA0.915
Rv3846sodA0.915
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
methionine sulfoxidePubChem0.841165.211
ecdysonePubChem0.783464.635
hydron sulfatePubChem0.714196.157
sulfatePubChem0.71496.0626
sulfoxidePubChem0.702324.478