Rv0032

Tuberculist information
Gene namebioF2
Protein functionPossible 8-amino-7-oxononanoate synthase BioF2 (AONS) (8-amino-7-ketopelargonate synthase) (7-keto-8-amino-pelargonic acid synthetase) (7-KAP synthetase) (L-alanine--pimelyl CoA ligase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)34.295
Molecular mass(da)86243.3
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 771
	  		  	1    MPTGLGYDFLRPVEDSGINDLKHYYFMADLADGQPLGRANLYSVCFDLATTDRKLTPAWR   60
			  	61   TTIKRWFPGFMTFRFLECGLLTMVSNPLALRSDTDLERVLPVLAGQMDQLAHDDGSDFLM  120
			  	121  IRDVDPEHYQRYLDILRPLGFRPALGFSRVDTTISWSSVEEALGCLSHKRRLPLKTSLEF  180
			  	181  RERFGIEVEELDEYAEHAPVLARLWRNVKTEAKDYQREDLNPEFFAACSRHLHGRSRLWL  240
			  	241  FRYQGTPIAFFLNVWGADENYILLEWGIDRDFEHYRKANLYRAALMLSLKDAISRDKRRM  300
			  	301  EMGITNYFTKLRIPGARVIPTIYFLRHSTDPVHTATLARMMMHNIQRPTLPDDMSEEFCR  360
			  	361  WEERIRLDQDGLPEHDIFRKIDRQHKYTGLKLGGVYGFYPRFTGPQRSTVKAAELGEIVL  420
			  	421  LGTNSYLGLATHPEVVEASAEATRRYGTGCSGSPLLNGTLDLHVSLEQELACFLGKPAAV  480
			  	481  LCSTGYQSNLAAISALCESGDMIIQDALNHRSLFDAARLSGADFTLYRHNDMDHLARVLR  540
			  	541  RTEGRRRIIVVDAVFSMEGTVADLATIAELADRHGCRVYVDESHALGVLGPDGRGASAAL  600
			  	601  GVLARMDVVMGTFSKSFASVGGFIAGDRPVVDYIRHNGSGHVFSASLPPAAAAATHAALR  660
			  	661  VSRREPDRRARVLAAAEYMATGLARQGYQAEYHGTAIVPVILGNPTVAHAGYLRLMRSGV  720
			  	721  YVNPVAPPAVPEERSGFRTSYLADHRQSDLDRALHVFAGLAEDLTPQGAAL

Known structures in the PDB
No Known structures
1 78 155 232 309 386 463 540 617 694 771 Range: 5 to 322  |  Coverage: 41% DUF482 Range: 168 to 311  |  Coverage: 18% Acetyltransf_6 Range: 416 to 757  |  Coverage: 44% Aminotran_1_2 Range: 373 to 764  |  Coverage: 50% 1 Range: 416 to 757  |  Coverage: 44% 1
Number of amino acids : 771
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
DUF482PF043395-322
Acetyltransf_6PF13480168-311
Aminotran_1_2PF00155416-757
Mtb Structural Proteome models
Model Number1
Model nameRv0032
Template1FC4    APDBCREDO
Template coverage-1_394
Template Identity(%)31.6
Model coverage(%)50.7
Normalized DOPE score-0.427

Structure Models from Chopin
Model Number1
Profilec.67.1.9
Click for model details
zscore17.93
Residue begin416
Residue end757
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0032Gene nameConfidence Score
Rv1568bioA0.97
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
7-keto-8-aminopelargonic acidPubChem0.927187.236
pimeloyl-CoAPubChem0.927909.687
8-amino-7-oxononanoic acidPubChem0.918187.236