SInCRe - Rv3529c

Tuberculist information

Gene name	Rv3529c
Protein function	Conserved hypothetical protein
Functional category(tuberculist)	conserved hypotheticals
Gene location(kb)	3965.88
Molecular mass(da)	43345.8
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 384

	  		  	1    MTRRPDRKDVATVDELHASATKLVGLDDFGTDDDNYREALGVLLDAYQGEAGLTVLGSKM   60
			  	61   NRFFLRGALVARLLSQSAWKQYPEHVDVAIKRPIFVTGLVRTGTTALHRLLGADPAHQGL  120
			  	121  HMWLAEYPQPRPPRETWESNPLYRQLDAQFTQHHAENPGYTGLHFMAAYELEECWQLLRQ  180
			  	181  SLHSVSYEALAHVPSYADWLSRQDWTPSYCRHRRNLQLIGLNDAEKRWVLKNPSHLFALD  240
			  	241  ALMATYPDALVVQTHRPVETIMASMCSLAQHTTEGWSTKFVGAQIGADAMDTWSRGLERF  300
			  	301  NAARAKYDSAQFYDVDYHDLIADPLGTVADIYRHFGLTLSDEARQAMTTVHAESQSGARA  360
			  	361  PKHSYSLADYGLTVEMVKERFAGL

Known structures in the PDB

	PDB ID	2ZQ5
	Total residue count	384
	Number of chains	1
	Method	X-RAY
	Resolution	2

Number of amino acids : 384

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
Sulfotransfer_3	PF13469	92-342

Mtb Structural Proteome models

Model Number	1
Model name	Rv3529c_2zq5_A
Template	2ZQ5 APDB CREDO
Template coverage	7_384
Template Identity(%)	100.0
Model coverage(%)	98.2
Normalized DOPE score	-1.852

Model Number	2
Model name	Rv3529c
Template	2GWH APDB CREDO
Template coverage	37_248
Template Identity(%)	13.2
Model coverage(%)	56.5
Normalized DOPE score	0.075

Structure Models from Chopin

Model Number	1
Profile	c.37.1.5 - 3.40.50.300 Click for model details
zscore	5.84
Residue begin	24
Residue end	384

Binding pockets

STRING

Cytoscape Web will replace the contents of this div with protein-protein interaction network.

Protein interacting with Rv3529c	Gene name	Confidence Score
Rv3531c	Rv3531c	0.981
Rv3530c	Rv3530c	0.908

Potential ligand/drug binding sites

Protein Model	Pocket Number	Drug Binding Site	PMIN Score	Pvalue PMIN	PMAX Score	Pvalue PMAX
Rv3529c_2zq5_A	1	1xkk_FMM_A_91 PDB CREDO	0.587	0.195	0.587	0.003
Rv3529c_2zq5_A	2	3d91_REM_A_350 PDB CREDO	0.583	0.200	0.583	0.003
Rv3529c_2zq5_A	2	3d91_REM_B_350 PDB CREDO	0.581	0.203	0.581	0.003
Rv3529c_2zq5_A	1	1t46_STI_A_3 PDB CREDO	0.593	0.187	0.563	0.004
Rv3529c_2zq5_A	1	2xkw_P1B_A_1478 PDB CREDO	0.577	0.207	0.563	0.004
Rv3529c_2zq5_A	1	1uwj_BAX_A_1723 PDB CREDO	0.674	0.102	0.557	0.004
Rv3529c_2zq5_A	2	1z2b_VLB_C_800 PDB CREDO	0.569	0.218	0.552	0.005
Rv3529c_2zq5_A	1	3gp0_NIL_A_1 PDB CREDO	0.563	0.226	0.549	0.005
Rv3529c_2zq5_A	2	2vn1_FK5_A_501 PDB CREDO	0.632	0.143	0.548	0.005
Rv3529c_2zq5_A	2	1uwj_BAX_B_1723 PDB CREDO	0.547	0.248	0.547	0.005
Rv3529c_2zq5_A	2	3ua1_08Y_A_600 PDB CREDO	0.636	0.138	0.546	0.005
Rv3529c_2zq5_A	2	1uob_PNN_A_1311 PDB CREDO	0.560	0.230	0.543	0.006
Rv3529c_2zq5_A	2	1uwj_BAX_A_1723 PDB CREDO	0.592	0.188	0.543	0.006
Rv3529c_2zq5_A	1	3bjw_SVR_B_501 PDB CREDO	0.540	0.258	0.540	0.006
Rv3529c_2zq5_A	2	3nxu_RIT_A_600 PDB CREDO	0.640	0.135	0.539	0.006
Rv3529c_2zq5_A	2	2x9g_LYA_A_1270 PDB CREDO	0.629	0.146	0.539	0.006
Rv3529c_2zq5_A	1	3bjw_SVR_H_504 PDB CREDO	0.538	0.261	0.538	0.006
Rv3529c_2zq5_A	2	3apw_DP0_A_190 PDB CREDO	0.668	0.107	0.537	0.006
Rv3529c_2zq5_A	1	3bjw_SVR_E_503 PDB CREDO	0.579	0.204	0.535	0.006
Rv3529c_2zq5_A	2	3nxu_RIT_B_600 PDB CREDO	0.633	0.142	0.534	0.006
Rv3529c_2zq5_A	1	3bjw_SVR_F_502 PDB CREDO	0.534	0.267	0.534	0.006
Rv3529c_2zq5_A	1	3b0w_DGX_B_1 PDB CREDO	0.614	0.163	0.522	0.008
Rv3529c_2zq5_A	2	1uwh_BAX_A_1723 PDB CREDO	0.555	0.237	0.522	0.008
Rv3529c_2zq5_A	2	1uwh_BAX_B_1723 PDB CREDO	0.554	0.239	0.522	0.008
Rv3529c_2zq5_A	1	1hwk_117_B_1 PDB CREDO	0.641	0.134	0.515	0.009
Rv3529c_2zq5_A	2	3vn2_TLS_A_501 PDB CREDO	0.562	0.227	0.513	0.009
Rv3529c_2zq5_A	2	2w8y_486_A_1000 PDB CREDO	0.512	0.300	0.512	0.009
Rv3529c_2zq5_A	2	2x9g_LYA_B_1270 PDB CREDO	0.656	0.119	0.510	0.009
Rv3529c_2zq5_A	1	3bjw_SVR_G_506 PDB CREDO	0.536	0.263	0.509	0.009
Rv3529c_2zq5_A	1	1uwj_BAX_B_1723 PDB CREDO	0.670	0.106	0.508	0.010
Rv3529c_2zq5_A	2	2f38_15M_A_325 PDB CREDO	0.553	0.239	0.505	0.010
Rv3529c_2zq5_A	1	3cs9_NIL_C_600 PDB CREDO	0.531	0.271	0.504	0.010
Rv3529c_2zq5_A	1	3sm2_478_A_126 PDB CREDO	0.529	0.274	0.503	0.010
Rv3529c_2zq5_A	1	3cs9_NIL_D_600 PDB CREDO	0.529	0.273	0.502	0.011
Rv3529c_2zq5_A	2	2hyy_STI_C_600 PDB CREDO	0.532	0.269	0.502	0.011
Rv3529c_2zq5_A	2	3pyy_STI_A_3 PDB CREDO	0.532	0.269	0.502	0.011
Rv3529c_2zq5_A	2	2hyy_STI_D_600 PDB CREDO	0.532	0.270	0.502	0.011
Rv3529c_2zq5_A	1	3bjw_SVR_C_505 PDB CREDO	0.543	0.254	0.502	0.011
Rv3529c_2zq5_A	1	3bjw_SVR_B_512 PDB CREDO	0.501	0.316	0.501	0.011
Rv3529c_2zq5_A	2	1fap_RAP_A_108 PDB CREDO	0.610	0.168	0.501	0.011

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

No high confidence interactions