Rv0824c

Tuberculist information
Gene namedesA1
Protein functionProbable acyl-[acyl-carrier protein] desaturase DesA1 (acyl-[ACP] desaturase) (stearoyl-ACP desaturase) (protein Des)
Functional category(tuberculist)lipid metabolism
Gene location(kb)917.734
Molecular mass(da)38770.2
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 338
	  		  	1    MSAKLTDLQLLHELEPVVEKYLNRHLSMHKPWNPHDYIPWSDGKNYYALGGQDWDPDQSK   60
			  	61   LSDVAQVAMVQNLVTEDNLPSYHREIAMNMGMDGAWGQWVNRWTAEENRHGIALRDYLVV  120
			  	121  TRSVDPVELEKLRLEVVNRGFSPGQNHQGHYFAESLTDSVLYVSFQELATRISHRNTGKA  180
			  	181  CNDPVADQLMAKISADENLHMIFYRDVSEAAFDLVPNQAMKSLHLILSHFQMPGFQVPEF  240
			  	241  RRKAVVIAVGGVYDPRIHLDEVVMPVLKKWRIFEREDFTGEGAKLRDELALVIKDLELAC  300
			  	301  DKFEVSKQRQLDREARTGKKVSAHELHKTAGKLAMSRR

Known structures in the PDB
No Known structures
1 34 67 100 133 166 199 232 265 298 331 Range: 4 to 326  |  Coverage: 95% FA_desaturase_2 Range: 9 to 278  |  Coverage: 79% 1 Range: 1 to 326  |  Coverage: 96% 2 Range: 3 to 338  |  Coverage: 99% 1
Number of amino acids : 338
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
FA_desaturase_2PF034054-326
Mtb Structural Proteome models
Model Number1
Model nameRv0824c
Template1ZA0    APDBCREDO
Template coverage9_269
Template Identity(%)33.1
Model coverage(%)79.6
Normalized DOPE score-0.744

Model Number2
Model nameRv0824c.1
Template1AFR    APDBCREDO
Template coverage32_361
Template Identity(%)23.3
Model coverage(%)96.2
Normalized DOPE score-0.563

Structure Models from Chopin
Model Number1
Profilea.25.1.3
Click for model details
zscore5.33
Residue begin3
Residue end338
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0824cGene nameConfidence Score
Rv2524cfas0.901
Rv2524cfas0.901
Rv2524cfas0.901
Rv2524cfas0.901
Rv2524cfas0.901
Rv2524cfas0.901
Rv2524cfas0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions